In this large cohort of patients with NAFLD and DM, use of metformin was associated with a reduced risk of HCC, whereas use of combination therapy was associated with increased risk. Adequate glycemic control was associated with a 31% lower risk of HCC (HR, 0.69 95% CI, 0.62–0.78). If the journal is published by a scientific society of which you are a member, the price is likely discounted for you. Insulin in combination with other oral medications was associated with a 1.6 to 1.7-fold higher risk of HCC. Check for the date right under the title or at the start of the article’s text. Most news sites and blogs will list the date underneath the title of the article, along with the name of the author. Insulin had no effect on HCC risk (HR, 1.02 95% CI, 0.85–1.22 p = 0.85). Look underneath the headline of an article or blog post. Compared with no medication, metformin was associated with 20% lower risk of HCC (HR, 0.80 95% CI, 0.93–0.98). Most common treatments were metformin monotherapy (19.7%), metformin-sulfonylureas (19.6%), insulin (9.3%), and sulfonylureas monotherapy (13.6%). In total, 524 patients developed HCC during a mean of 10.3 years of follow-up. We identified 85,963 patients with NAFLD and DM. We used landmark Cox proportional hazards models to determine the effects of anti-DM medications (metformin, insulin, sulfonylureas) and glycemic control (percent of follow-up time with hemoglobin A1c < 7%) on the risk of HCC while adjusting for demographics and other metabolic traits (hypertension, obesity, dyslipidemia). We followed patients from the date of NAFLD diagnosis to HCC, death, or.
We assembled a retrospective cohort of patients with NAFLD and DM diagnosed at 130 facilities in the Veterans Administration between and. Managerial Finance provides an international forum for the publication of high quality and topical research across. However, the determinants of HCC risk in these patients remain unclear.
In patients with NAFLD, those with type 2 diabetes mellitus (DM) have a high risk of progression to HCC.
0 kommentar(er)
